The ultimate goal is to facilitate brain function preservation and recovery in patients undergoing complex brain surgery. The latest innovation is the reconstruction of cranial nerves for presurgical evaluation in skull base surgery, with very promising results. We are actively investigating its potential for not only presurgical planning and intraoperative navigation but also for neurostructural damage assessment, estimation of postsurgical neural pathways damage and recovery, and tracking of postsurgical changes and responses to rehabilitation therapy. Our clinical experience applying DSI Studio fiber tracking has been reported in Neurosurgery, Journal of Neurosurgery, and Neuro-oncology among others. Presurgical studies are built upon precise and accurate neuroanatomical knowledge, which allows doctors to reconstruct perilesional or intralesional fiber tracts, design the less invasive trajectory into the target lesion and apply more effectively intraoperative electrical mapping techniques for maximal and safe tumor resection in eloquent cortical and subcortical regions. Usage in Clinical Medicine for Tumor PatientsĪlthough not yet FDA cleared, under the research projects, DSI Studio has helped more than 200 brain tumor patients at the University of Pittsburgh Medical Center:įiber tracking in DSI Studio provides a superior presurgical evaluation of the fiber tracts for patients with complex brain lesions, including low-grade and high-grade gliomas. The average accuracy of the tools is only 54%.ĭSI Studio tractography performance ID:03 The deterministic fiber tracking method in DSI Studio has achieved the highest 92% valid connection (ID#3) among 96 methods submitted from 20 different research groups, examined by an open competition (Nature communications, 8(1), 1349, 2017). Research studies using DSI Studio have been published in top-tier journals including Nature Neuroscience, Nature Human Behavior, Nature Communication, Brain, Cerebral Cortex, and NeuroImageĭSI Studio tractography on the cover of “Nature Reviews Neurology” for the whole year of 2017.Ībout the cover. It is a collective implementation of several diffusion MRI methods, including diffusion tensor imaging (DTI), generalized q-sampling imaging (GQI), q-space diffeomorphic reconstruction (QSDR), diffusion MRI connectometry, and generalized deterministic fiber tracking.Ī screenshot of DSI Studio mapping tractography of the arcuate fasciculusĭSI Studio has facilitated and been used in more than 1,400 publications.
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